5F-ADB (also known as 5F-MDMB-PINACA) is an indazole-based synthetic cannabinoid from the indazole-3-carboxamide family, which has been used as an active ingredient in synthetic cannabis products and has been sold online as a designer drug.
5F-ADB is a potent agonist of the CB1 receptor, though it is unclear whether it is selective for this target. 5F-ADB was first identified in November 2014 from post-mortem samples taken from an individual who had died after using a product containing this substance.
Subsequent testing identified 5F-ADB to have been present in a total of ten people who had died from unexplained drug overdoses in Japan between September 2014 and December 2014, and it was added to the Japanese banned drug list in December 2014.
5F-ADB is believed to be extremely potent based on the very low levels detected in tissue samples, and appears to be significantly more toxic than earlier synthetic cannabinoid drugs that had previously been sold.
In the United States, 5F-ADB is a Schedule I controlled substance.
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Synthetic cannabinoids have been synthesized at an astonishing rate due to their interesting receptor binding profiles for the cannabinoid receptor subgroup. Buy 5F-ADB cannabinoids online
Despite many years of strict cannabis prohibition, the USA has seen a marijuana movement in the past 2 years which has allowed for a fascinating growth of chemical and pharmacological data surrounding cannabinoids.
5F-MDMB-PINACA (AKA 5F-ADB, 5-fluoro ADB or 5-fluoro MDMB-PINACA) is part of this steady stream of synthetic cannabinoids with chemical similarities to that of the well-studied AKB48 or APINACA.
AKB48 is a potent cannabinoid receptor agonist and as such 5F-MDMB-PINACA is thought to also possess this property.
AKB48’s derivatives have usually seen its terminal carbon atom with an additional fluorine attached to the pentyl group.
However, 5F-MDMB-PINACA has a slight change to this theme with a terminal amide (normally seen with ADP-PINACA) exchanged for a methyl ester.
This makes 5F-MDMB-PINACA a novel tool for any well-equipped laboratory.