Description

Buy hydromorphone online

Hydromorphone, also known as dihydromorphinone is a morphinan opioid used to treat moderate to severe pain. The hydromorphone extended-release capsules and extended-release tablets are used to relieve pain in opioid-tolerant patients severe enough to require around-the-clock pain relief for a long period of time. Buy Hydromorphone online

Hydromorphone extended-release capsules and extended-release tablets should not be used if you need pain medicine for just a short time, such as when recovering from surgery. Do not use this medicine to relieve mild pain. This medicine should not be used to treat pain that you only have once in a while or “as needed”.

Hydromorphone belongs to the group of medicines called narcotic analgesics (pain medicines). It acts on the central nervous system (CNS) to relieve pain. Buy Hydromorphone online

When a narcotic medicine is used for a long time, it may become habit-forming, causing mental or physical dependence. However, people who have continuing pain should not let the fear of dependence keep them from using narcotics to relieve their pain. Mental dependence (addiction) is not likely to occur when narcotics are used for this purpose. Buy Hydromorphone online

Physical dependence may lead to withdrawal side effects if treatment is stopped suddenly. However, severe withdrawal side effects can usually be prevented by gradually reducing the dose over a period of time before treatment is stopped completely. Buy Hydromorphone online

This medicine is available only under a restricted distribution program called the Opioid Analgesic REMS (Risk Evaluation and Mitigation Strategy) program.

This product is available in the following dosage forms:

Tablet, Extended Release
Tablet
Solution

Hydromorphone is structurally very similar to morphine; it differs from morphine by the presence of a 6-keto group and the hydrogenation of the double bond at the 7-8 position of the molecule. Like morphine, it acts primarily on opioid receptors, and to a lesser degree on delta receptors. Hydromorphone does not effect kappa, sigma, or epsilon receptors. receptors mediate the pain relieving properties of opioids but also mediate unwanted side effects, such as constipation, nausea, and respiratory depression. Buy Hydromorphone online

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How are they abused?

Hydromorphone belongs to a class of drugs called “opioids,” which includes morphine. It has an analgesic potency approximately two to eight times greater than that of morphine and has a rapid onset of action. Injectable solutions, as well as tablets that have been crushed and dissolved in a solution may be injected as a substitute for heroin. Buy Hydromorphone online

What is their effect on the body?

Euphoria, relaxation, sedation, and reduced anxiety. It may also cause mental clouding, changes in mood, nervousness, and restlessness Constipation, nausea, vomiting, impaired coordination, loss of appetite, rash, slow or rapid heartbeat, and changes in blood pressure. Buy Hydromorphone online

What are its overdose effects?

Acute overdose of hydromorphone can produce: Severe respiratory depression, drowsiness progressing to stupor or coma, lack of skeletal muscle tone, cold and clammy skin, constricted pupils, and reduction in blood pressure and heart rate. Severe overdose may result in death due to respiratory depression. Buy Hydromorphone online

Hydromorphone for Acute Pain

				Results
Comparison Drug	Reference	Patients (n)	Equianalgesic Ratio Used	Pain Control	Adverse Effects
Oral HM vs. placebo	Goldberg 1965 ⁵⁸	30	—	All patients using HM and 30% of placebo group had some pain relief.	No significant difference.
	Jain 1989 ⁵⁹	61	—	HM statistically superior to placebo.	No significant difference.
Epidural HM vs. placebo/ fentanyl/sufentanil	Parker 1985 ⁶⁰	21	—	All patients except placebo group had pain relief with same onset.	Respiratory depression (RR < 10/min) found in 1 F and 2 HM group.
				Duration of action 5× longer for HM.
Epidural HM vs. morphine	5 studies ⁹ ^, ¹⁰ ^, ²⁴ ^, ⁶¹ ^, ⁶²	278	HM :M = 7:1–5:1	No significant difference in pain relief.	3 studies—no difference;
					2 studies—lower incidence of pruritis with HM.
Parenteral (IV or IM) HM vs. morphine	several studies ⁶ ^, ¹² ^, ²⁰ ^, ⁴⁰ ^, ⁶³ ^, ⁶⁴ ^, ⁶⁵ ^, ⁶⁶	467	HM :M = 7:1–5:1	No significant difference in pain relief except in one study where morphine superior in time to treatment failure. ²⁰	7 studies showed no difference;
					1 study—lower incidence nausea/pruritis but poorer cognitive function in HM group;
					1 study—lower side effects in morphine group.
Intramuscular HM vs. diamorphine	Wallenstein 1990 ⁶⁷	208	HM:diamorphine = 4.5–5.5:1	No significant difference.	No significant difference.
HM vs. meperidine	4 studies ⁶⁴ ^, ⁶⁸ ^, ⁶⁹ ^, ⁷⁰	346		HM more effective.	No significant difference.
Oral HM vs. oral transmucosal fentanyl	Sharar 1998 ⁷¹	14	HM:fentanyl = 1:6	Fentanyl had increased pain relief at 30 minutes but overall efficacy same.	No significant difference.
Epidural HM vs. bupivacaine	Chestnut 1986 ²⁵	52		HM more effective.	No significant difference.
HM (SC) vs. indomethacin (IV)	Uden 1984 ⁷²	30		No significant difference.	Longer duration of nausea and vertigo with HM.

HM = hydromorphone; M = morphine; IV = intravenous; IM = intramuscular; SC = subcutaneous.

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